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The following is quoted from -The Melanoma FAQ
Melanoma is a type of cancer, originating in the melanocytes, the cells containing color.
Melanoma is most commonly classified in four Stages, determined by how deeply the cancer cells have penetrated the body. Stage I involves a mole or growth on the top layer of the skin. Stage II indicates that the growth is deeper but has not spread anywhere else in the body. Stage III is when the melanoma has spread to a nearby lymph basin (the most common) or other nearby tissues. Stage IV melanoma has spread to other more distant areas of the body. As you would logically assume, Stage I is less dangerous and easier to treat, and each higher stage is progressively more serious.
http://www.tustison.com/melfaq.html